{"id":151189,"date":"2021-11-02T14:59:49","date_gmt":"2021-11-03T00:59:49","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=151189"},"modified":"2021-11-02T15:14:13","modified_gmt":"2021-11-03T01:14:13","slug":"abdominal-fat-cancer-research","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2021\/11\/02\/abdominal-fat-cancer-research\/","title":{"rendered":"$5.6<abbr>M<\/abbr> for abdominal fat, cancer research in high-risk Hawai\u02bbi groups"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> 2<\/span> <span class=\"rt-label rt-postfix\">minutes<\/span><\/span><figure id=\"attachment_151208\" aria-describedby=\"caption-attachment-151208\" style=\"width: 676px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2021\/11\/manoa-cancer-center-boushay-app-1.jpg\" alt=\"smart phone taking pic of food\" width=\"676\" height=\"381\" class=\"size-full wp-image-151208\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2021\/11\/manoa-cancer-center-boushay-app-1.jpg 676w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2021\/11\/manoa-cancer-center-boushay-app-1-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2021\/11\/manoa-cancer-center-boushay-app-1-130x73.jpg 130w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><figcaption id=\"caption-attachment-151208\" class=\"wp-caption-text\">Study participants will take photos of their meals using a smartphone app.<\/figcaption><\/figure>\n<p><a href=\"http:\/\/www.uhcancercenter.org\">University of <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span> Cancer Center<\/a> researchers have received a five-year, $5.6 million grant to help reduce intra-abdominal fat, overall body fat and to improve cancer-related biomarkers and gut microbiome functions for high-risk ethnic groups in <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span>. The National Institutes of Health award will be used to conduct a 24-week randomized trial among overweight individuals comparing intermittent energy restriction (<abbr>IER<\/abbr>) to daily energy restriction (<abbr>DER<\/abbr>) interventions.<\/p>\n<ul>\n<li>Related <em><abbr title=\"University of Hawaii\">UH<\/abbr> News<\/em> story: <a href=\"https:\/\/www.hawaii.edu\/news\/2021\/10\/12\/16m-boost-for-uh-cancer-research\/\">$16<abbr title=\"million\">M<\/abbr> boost for <abbr>UH<\/abbr> cancer research<\/a>, October 12, 2021<\/li>\n<\/ul>\n<h2>Study with local ethnic groups<\/h2>\n<p>To further study the benefits of <abbr>IER<\/abbr>, <abbr>UH<\/abbr> Cancer Center researchers and principal investigators <strong>Lo\u00efc Le Marchand<\/strong>, <strong>Carol Boushey<\/strong> and <strong>Unhee Lim<\/strong>, will conduct the study using an <abbr>IER<\/abbr> protocol or <abbr>DER<\/abbr> protocol combined with a Mediterranean dietary pattern among 260 middle-aged <span aria-label=\"Oahu\">O&#699;ahu<\/span> residents of Asian, Native Hawaiian\/Pacific Island or white ethnicity. <\/p>\n<p>&ldquo;People with large amounts of fat inside their abdomen are at a particularly high risk of diabetes, heart disease and some types of cancers, including breast cancer,&rdquo; said Le Marchand. &ldquo;We believe such individuals will lose enough of this &lsquo;visceral fat&rsquo; to reduce their risk of disease by following a diet with a reduced caloric intake during two consecutive days of the week for six months\u2014which may be easier and more effective than a daily reduction in calories.&rdquo;<\/p>\n<p>The intervention will be delivered through customized consultations with a research dietitian. The research dietitians will monitor dietary compliance using photos taken by the participants of their meals using a smartphone app.<\/p>\n<p>&ldquo;We have done extensive work demonstrating that following a healthy dietary pattern, such as the Healthy Eating Index or the Mediterranean dietary pattern, rich in whole grains and fruits and vegetables, leads to reductions in cancer risk,&rdquo; said Boushey. &ldquo;This randomized study will add unique temporal data, and we are so lucky our <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span> community will have a chance to potentially benefit from the study.&rdquo;<\/p>\n<h2><abbr>IER<\/abbr> versus <abbr>DER<\/abbr> interventions<\/h2>\n<p>In <a href=\"https:\/\/www.mdpi.com\/2072-6643\/11\/6\/1386\/htm\">previous studies<\/a>, <abbr>UH<\/abbr> Cancer Center researchers have identified striking ethnic and racial disparities in their predisposition to accumulate intra-abdominal fat and in the strength of the association between obesity and cancer risk. To reduce these disparities, the researchers investigated the use of an <abbr>IER<\/abbr> dietary intervention to decrease intra-abdominal fat and improve gut microbiome composition.<\/p>\n<p>Researchers have found that <abbr>IER<\/abbr> interventions are more easily maintained and have a greater beneficial effect compared to <abbr>DER<\/abbr>. <abbr>IER<\/abbr> interventions require an individual to restrict calories only a few days out of the week, whereas many weight-control programs use <abbr>DER<\/abbr> interventions, which require an individual to restrict calories daily.<\/p>\n<p><abbr>UH<\/abbr> researchers hope to better understand how <abbr>IER<\/abbr> combined with a healthy diet may be able to lower cancer-related risk and inform future dissemination research to reduce cancer risk in various high-risk ethnic groups in <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span> and elsewhere.<\/p>\n<p>This research is an example of <abbr>UH<\/abbr> M\u0101noa\u2019s goal of <a href=\"https:\/\/manoa.hawaii.edu\/wp\/wp-content\/uploads\/2020\/12\/manoa-2025-strategic-plan.pdf#page=25\">Excellence in Research: Advancing the Research and Creative Work Enterprise<\/a> (<span class=\"small-text\"><abbr title=\"Portable Document Format\">PDF<\/abbr><\/span>), one of four goals identified in the 2015\u201325 Â鶹´«Ã½ (<span class=\"small-text\"><abbr title=\"Portable Document Format\">PDF<\/abbr><\/span>), updated in December 2020.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The study hopes to lower cancer-related risk among individuals in various high-risk ethnic groups in <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span> and elsewhere. <\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[218,1467,1363,169,9],"class_list":["post-151189","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-manoa-excellence-in-research","tag-manoa-research","tag-uh-cancer-center","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/151189","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/users\/16"}],"replies":[{"embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/comments?post=151189"}],"version-history":[{"count":9,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/151189\/revisions"}],"predecessor-version":[{"id":151222,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/posts\/151189\/revisions\/151222"}],"wp:attachment":[{"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/media?parent=151189"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/categories?post=151189"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.hawaii.edu\/news\/wp-json\/wp\/v2\/tags?post=151189"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}