{"id":123522,"date":"2020-07-27T16:09:21","date_gmt":"2020-07-28T02:09:21","guid":{"rendered":"https:\/\/www.hawaii.edu\/news\/?p=123522"},"modified":"2020-07-27T16:10:06","modified_gmt":"2020-07-28T02:10:06","slug":"bap1-cancer-syndrome-publication","status":"publish","type":"post","link":"https:\/\/www.hawaii.edu\/news\/2020\/07\/27\/bap1-cancer-syndrome-publication\/","title":{"rendered":"Significance of gene mutations in cancers highlighted"},"content":{"rendered":"<span class=\"span-reading-time rt-reading-time\" style=\"display: block;\"><span class=\"rt-label rt-prefix\">Reading time: <\/span> <span class=\"rt-time\"> &lt; 1<\/span> <span class=\"rt-label rt-postfix\">minute<\/span><\/span><p><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/07\/manoa-cancer-center-carbone-microscope.jpg\" alt=\"Carbone looking into microscope\" width=\"676\" height=\"381\" class=\"aligncenter size-full wp-image-123556\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/07\/manoa-cancer-center-carbone-microscope.jpg 676w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/07\/manoa-cancer-center-carbone-microscope-300x169.jpg 300w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2020\/07\/manoa-cancer-center-carbone-microscope-130x73.jpg 130w\" sizes=\"auto, (max-width: 676px) 100vw, 676px\" \/><\/p>\n<p>An article explaining the biological and clinical characteristics of <abbr>BAP1<\/abbr> Cancer Syndrome, and highlighting the significance of <abbr>BAP1<\/abbr> mutations in human cancer, was recently published, with <a href=\"http:\/\/www.uhcancercenter.org\">University of <span aria-label=\"Hawaii\">Â鶹´«Ã½<\/span> Cancer Center<\/a> researcher <strong>Michele Carbone<\/strong> as lead author. Written in collaboration with scientists from five other institutions across the nation, it was published in <a href=\"https:\/\/cancerdiscovery.aacrjournals.org\/content\/early\/2020\/07\/19\/2159-8290.CD-19-1220\"><em>Cancer Discovery<\/em><\/a>.<\/p>\n<p>The <abbr>BAP1<\/abbr> Cancer Syndrome, caused by inherited mutations of the <abbr>BAP1<\/abbr> gene, was discovered by Carbone and his team at the <abbr title=\"University of Hawaii\">UH<\/abbr> Cancer Center in 2011. Since then, many affected individuals have been identified in the <abbr title=\"United States\">U.S.<\/abbr>, Europe, Australia, Japan and the Middle East.<\/p>\n<ul>\n<li>Related <em><abbr>UH<\/abbr> News<\/em> story: <a href=\"https:\/\/www.hawaii.edu\/news\/2019\/12\/17\/cancer-related-gene-nih-grant\/\">Cancer-related research leads to $2.6<abbr title=\"million\">M<\/abbr> grant<\/a>, December 17, 2019.<\/li>\n<\/ul>\n<p>This medical condition is characterized by the development of one and often multiple cancers in those who inherit mutations of the <abbr>BAP1<\/abbr> gene. The most common cancers being mesothelioma, uveal and cutaneous melanoma, and clear-cell renal cell carcinoma. <\/p>\n<figure id=\"attachment_80067\" aria-describedby=\"caption-attachment-80067\" style=\"width: 214px\" class=\"wp-caption alignright\"><img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2018\/05\/uh-cancer-center-carbone-m-214x300.jpg\" alt=\"\" width=\"214\" height=\"300\" class=\"size-medium wp-image-80067\" srcset=\"https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2018\/05\/uh-cancer-center-carbone-m-214x300.jpg 214w, https:\/\/www.hawaii.edu\/news\/wp-content\/uploads\/2018\/05\/uh-cancer-center-carbone-m.jpg 250w\" sizes=\"auto, (max-width: 214px) 100vw, 214px\" \/><figcaption id=\"caption-attachment-80067\" class=\"wp-caption-text\">Michele Carbone<\/figcaption><\/figure>\n<p>&ldquo;Identifying those who carry <abbr>BAP1<\/abbr> gene mutations allows the establishment of cancer prevention and early detection measures to save their lives,&rdquo; said Carbone.<\/p>\n<p>The National Cancer Institute is conducting a clinical trial in collaboration with Carbone\u2019s team, in which carriers of <abbr>BAP1<\/abbr> mutations are given annual medical, radiological and serological tests for early detection at no cost. When required, participants also receive therapeutic intervention.<\/p>\n<p>&ldquo;Thank you to all of the members of affected families, who donated their specimens to our research that allowed us to discover the cause and mechanisms responsible for the development of cancer in these individuals, and to our donors whose support is critical to conduct our research,&rdquo; said Carbone.<\/p>\n<p>Read more on the <a href=\"https:\/\/www.uhcancercenter.org\/about-us\/newsroom\/641-uh-cancer-center-publication-highlights-the-impact-of-bap1-mutations-on-cancer-development\"><abbr>UH<\/abbr> Cancer Center website<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p><abbr title=\"University of Hawaii\">UH<\/abbr> Cancer Center\u2019s Michele Carbone says establishing early detection measures for those who carry the BAP1 gene will save their lives.<\/p>\n","protected":false},"author":16,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[218,1363,158,169,9],"class_list":["post-123522","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-research","tag-cancer","tag-manoa-research","tag-publication","tag-uh-cancer-center","tag-uh-manoa","entry","has-media"],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.0.1 - aioseo.com -->\n\t<meta name=\"description\" content=\"University of Hawaii Cancer Center\u2019s Michele Carbone says establishing early detection measures for those who carry the BAP1 gene will save their lives.\" \/>\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"Â鶹´«Ã½News\"\/>\n\t<meta name=\"keywords\" content=\"uh manoa,uh cancer center,manoa research,cancer,publication,bap1 gene 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