For decades, scientists have studied whether oxygen-carrying liquids could help people breathe when their lungs are too damaged or underdeveloped to function normally. They have assumed those liquids could replace the lung’s natural surfactant—an ultrathin film that coats the tiny air sacs inside the lungs and prevents them from collapsing during breathing. Research from the University of 麻豆传媒 at 惭ā苍辞补 suggests that assumption may be incorrect.
A new three-year, $491,121 National Science Foundation (NSF) award will enable Professor Yi Zuo and his team to investigate one of the most fundamental unanswered questions in lung biophysics while developing a new generation of experimental tools that could advance biomedical engineering, materials science and future liquid breathing technologies.
“The oxygen-carrying liquid does not simply replace the lung’s natural surfactant,” said Zuo from the and the . “Instead, the two appear to work together at the interface between two liquids. Understanding how that interface behaves is essential if we want to improve future liquid ventilation technologies.”
A century-old problem with new implications
Scientists have studied the pulmonary surfactant for more than 70 years to understand how it works when we breathe air. Much less is known about how it behaves when the lungs are filled with oxygen-rich liquids.
Liquid ventilation, in which oxygen-carrying perfluorocarbon liquids (synthetic liquids that carry large amounts of oxygen) partially or completely replace air in the lungs, has long been investigated as a potential treatment for premature infants and patients suffering from severe respiratory failure. Researchers have also envisioned future applications in emergency medicine, deep-sea diving and human space exploration. However, much remains unknown about the basic mechanics of how these liquids interact inside the lungs.
Inventing a new scientific tool
A major objective of the project is developing a new experimental platform capable of studying molecular behavior at liquid-liquid interfaces. Current techniques were originally designed nearly a century ago to investigate films on water exposed to air. Those methods work well for traditional surface science but cannot adequately study the interface between two liquids.
Building upon technology invented in Zuo’s laboratory, the team is developing a small device that lets scientists watch how molecules gather and interact where two different liquids meet.
“This project is really about developing a new way of studying one of nature’s most important interfaces,” Zuo said. “Once we have the technology, it can be applied far beyond lung biology.”
Impact beyond medicine
Liquid-liquid interfaces play essential roles in biological systems, advanced manufacturing, biotechnology, drug delivery, energy technologies, food science and environmental engineering. The new instrumentation developed through this NSF project is expected to provide researchers with a versatile platform for investigating molecular self-assembly in many different applications.